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Design "best practice" for clusters in a server/vdi environment

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We have been running in a vSphere 4.1/View 4.6 environment (single cluster) for about two years now with very little problems.  We recently purchased new hardware (hosts) and are rebuilding our virtual environment using ESXi 5.1/View 5.1/Unidesk.  My question is does anyone see any benefit to creating separate clusters in vCenter for servers/desktops?  I can't seem to find any documentation on the subject and was wondering what others are doing?


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